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Updated: Jul 14, 2026
07:29
Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis
Published on: May 16, 2020
Abnormal keratin expression in circumscribed palmar hypokeratosis
Akira Ishiko1, Itaru Dekio, Atsushi Fujimoto
1Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan. ishiko@sc.itc.keio.ac.jp
Journal of the American Academy of Dermatology
|June 8, 2007
Summary
Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin condition. Analysis of two cases suggests a hyperproliferative epidermis and fragile corneocytes contribute to its unique presentation.
Area of Science:
- Dermatology
- Pathology
- Microbiology
Background:
- Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin disorder.
- This study investigates the diagnostic features and pathogenesis of CPH.
Observation:
- Dermoscopy revealed characteristic step-like desquamation, erythema, and whitish spots.
- Immunohistochemistry showed altered keratin expression (increased keratin 16, decreased keratin 2e).
- Electron microscopy indicated corneocyte fragility with intact cell attachments.
Findings:
- Human papillomavirus (HPV) and specific bacteria were not detected in the lesions.
- The study analyzed two new Japanese cases of CPH.
- Key diagnostic features were identified through dermoscopy and microscopic analysis.
Implications:
- CPH may result from a hyperproliferative epidermal state combined with increased corneocyte fragility.
- Understanding these features aids in diagnosing and potentially managing this rare skin condition.
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