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Viral proteomics.

Karen L Maxwell¹, Lori Frappier

¹Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Microbiology and Molecular Biology Reviews : MMBR

|June 8, 2007

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Proteomics and structural biology advance our understanding of viruses. These methods reveal virion composition, protein interactions, and host cell changes during viral infection, aiding antiviral therapy development.

Area of Science:

Virology
Proteomics
Structural Biology

Background:

Viruses are studied for disease, molecular processes, and cellular pathway identification.
Proteomic approaches and mass spectrometry enhance detection of viral components and interactions.
High-resolution viral protein structures inform mechanisms and inhibitor design.

Purpose of the Study:

To review proteomic studies on eukaryotic viruses and bacteriophages.
To cover virion composition, viral protein structures, and protein interactions.
To discuss viral infection-induced changes in the cellular proteome.

Main Methods:

Proteomic analysis of virion components.
Mass spectrometry for detecting protein interactions.

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High-resolution structural determination of viral proteins.

Main Results:

Comprehensive understanding of viral infection mechanisms.
Identification of virus-virus and virus-host protein interactions.
Detailed analysis of virally induced changes in cellular proteomes.

Conclusions:

Proteomics and structural biology are crucial for understanding viral biology.
These approaches facilitate the development of targeted antiviral therapies.
Integrated analysis provides a holistic view of viral dynamics and host responses.