Related Experiment Video

Updated: Jul 14, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

A prospective study of rotavirus diarrhea in children under 1 year of age

Sudipta Misra1, Tapas K Sabui, Swati Basu

  • 1Department of Pediatrics, UIC College of Medicine at Peoria, Peoria, Illinois 61603, USA. smisra@uic.edu

Clinical Pediatrics
|June 8, 2007
PubMed

Insights

Rotavirus infection significantly hinders nutritional recovery in infants with acute diarrhea, despite breastfeeding. Universal rotavirus vaccination is recommended due to breastfeeding

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Gastroenterology

Background:

  • Acute diarrhea is a common pediatric illness.
  • Understanding its clinical profile and prognosis in infants is crucial for effective management.
  • Rotavirus is a leading cause of severe diarrhea in infants worldwide.

Purpose of the Study:

  • To document the changing clinical profile and prognosis of acute diarrhea in infants.
  • To investigate the impact of rotavirus infection on infant recovery.
  • To assess the role of breastfeeding and lactose malabsorption in acute diarrhea outcomes.

Main Methods:

  • Prospective observational study with follow-up.
  • Collection of demographic, anthropometric, and clinical data in infants (<1 year) with acute diarrhea.
  • Microscopic stool examination, culture, reducing substance and occult blood testing, and rotavirus detection via electrophoresis.

Main Results:

  • A high incidence of rotavirus infection (67.6%) was observed.
  • Rotavirus infection was associated with slower nutritional recovery in affected infants.
  • Lactose malabsorption (reducing substance in stool) was common (67.6%) but did not affect prognosis.
  • Exclusive breastfeeding did not prevent rotavirus infection.

Conclusions:

  • Rotavirus infection negatively impacts infant growth through an unclear mechanism.
  • The ineffectiveness of exclusive breastfeeding against rotavirus underscores the need for universal rotavirus vaccination.
  • Lactose malabsorption in infants with acute diarrhea does not appear to influence prognosis.

More Related Videos

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins11:40

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

Related Concept Videos

Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...