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08:18
Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
[Niacin in therapy]
Andrzej Nagalski1, Jadwiga Bryła
1Zakład Regulacji Metabolizmu, Instytut Biochemii, Wydział Biologii, Uniwersytet Warszawski, Warszawa, Poland.
Postepy Higieny I Medycyny Doswiadczalnej (Online)
|June 8, 2007
Summary
Niacin, a vital vitamin, effectively manages lipid disorders and cardiovascular disease by improving cholesterol levels. Careful niacin preparation and dosage are crucial to minimize potential side effects like flushing and hepatotoxicity.
Area of Science:
- Biochemistry
- Nutritional Science
- Pharmacology
Context:
- Niacin (nicotinic acid and nicotinamide) is essential for NAD+ and NADP+ coenzyme synthesis, vital for metabolic processes.
- Low dietary niacin levels can lead to pellagra, a deficiency disease.
- Niacin has a long history in treating dyslipidemia and preventing atherosclerosis.
Purpose:
- To review the multifaceted roles of niacin in human health and disease.
- To highlight niacin's efficacy in managing lipid profiles and its potential therapeutic applications beyond cardiovascular health.
- To discuss the side effects of niacin and emerging strategies for mitigating them.
Summary:
- Niacin significantly improves lipid profiles by increasing HDL cholesterol and reducing atherogenic lipoproteins (VLDL, LDL, Lp(a)), fatty acids, and triglycerides.
- Beyond lipid management, niacin shows promise in treating conditions like migraine, hyperphosphatemia, ethanol-induced neurodegeneration, and type 1 diabetes.
- Niacin's mechanism involves the G-protein-coupled receptor GPR109A, which mediates its effects on adipocytes and vasodilation, offering targets for new drug development.
Impact:
- Niacin remains a cornerstone therapy for dyslipidemia, contributing to cardiovascular disease prevention.
- Emerging research suggests broader therapeutic potential for niacin in various metabolic and systemic diseases.
- Understanding niacin's receptor interactions facilitates the development of safer and more effective niacin-based therapies with reduced side effects.
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