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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Enoxaparin therapy for arterial thrombosis in infants with congenital heart disease

Joe Bontadelli1, Alexander Moeller, Markus Schmugge

  • 1Division of Pediatrics, University Children's Hospital, Steinwiesstrasse 75, 8032 Zurich, Switzerland.

Intensive Care Medicine
|June 8, 2007
PubMed

Insights

Enoxaparin effectively treats arterial thrombosis in infants with congenital heart disease. This study found it safe and efficient, with 91% thrombosis resolution and minimal bleeding complications.

Area of Science:

  • Pediatric Cardiology
  • Neonatal Thrombosis Management
  • Pharmacology

Background:

  • Catheter-related arterial thrombosis is a serious complication in infants with congenital heart disease.
  • Current treatment often involves unfractionated heparin, but alternatives are being explored.

Purpose of the Study:

  • To evaluate the efficacy and safety of enoxaparin in treating catheter-related arterial thrombosis in infants with congenital heart disease.

Main Methods:

  • A prospective observational study was conducted in a pediatric intensive care and cardiology unit.
  • 32 infants (0-12 months) with catheter-related arterial thrombosis received enoxaparin.
  • Dose requirements, thrombosis resolution via Doppler ultrasound, and bleeding complications were assessed.

Main Results:

  • Complete resolution of thrombosis occurred in 91% of infants within a mean of 23 days.
  • Newborns required higher enoxaparin doses than older infants to achieve therapeutic levels.
  • Only one infant (3%) experienced bleeding complications.

Conclusions:

  • Enoxaparin demonstrates high efficacy and safety for treating catheter-related arterial thrombosis in this pediatric population.
  • It may serve as a viable alternative to unfractionated heparin for these patients.
Abstract

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