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Published on: January 26, 2024
[Antiphospholipid syndrome and preeclampsia]
1Unita' di Nefrologia, Cattedra di reumatologia, DPMSC, Universita' degli Studi, Udine - Italy.
Summary
Antiphospholipid antibody syndrome (APS) increases the risk of severe preeclampsia. This review details treatments like low-dose aspirin and heparin to prevent severe preeclampsia in APS patients.
Area of Science:
- Obstetrics and Gynecology
- Rheumatology
- Maternal-Fetal Medicine
Context:
- Preeclampsia is a common pregnancy complication, a leading cause of fetal mortality after 20 weeks.
- Severe preeclampsia involves specific hypertension, proteinuria levels, or organ involvement.
- Antiphospholipid antibody syndrome (APS) is a known risk factor for severe preeclampsia.
Purpose:
- To review and update the best available treatments for preventing severe preeclampsia in patients with APS.
- To outline a pharmacological approach for managing APS during pregnancy.
Summary:
- Preeclampsia is defined by gestational hypertension and proteinuria, with severe forms involving higher thresholds or specific complications.
- APS is a predisposing condition for severe preeclampsia.
- This review focuses on preventing the progression of APS to severe preeclampsia.
Impact:
- Highlights the importance of a multidisciplinary team for managing pregnant APS patients.
- Proposes a treatment strategy using low-dose salicylate and/or low molecular-weight heparin.
- Aims to improve outcomes for pregnant individuals with APS by mitigating preeclampsia risks.
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