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Updated: Jul 14, 2026
Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
Published on: March 20, 2026
[Expression and significance of TRAIL protein and mRNA in hemangioma]
Hui Lin1, Shi-Hai Chen, Guo-Qian Yin
1Department of Laser and Plastic Surgery, The First Affiliation Hospital of Guangxi Traditional Chinese Medical University. Nanning 530023, China.
Objective:
To detect the expression of TRAIL protein and mRNA in hemangiomas and vascular malformations.
Methods:
Sections of 33 proliferative hemangiomas,28 involuting hemangiomas and 29 vascular malformations were immunostained for TRAIL protein, TRAIL mRNA was examined by in situ hybridization in these tissue.
Results:
The TRAIL protein positive rates in proliferative hemangiomas, involuting hemangiomas, vascular malformations and normal skins were respectively 45.45% (15/33), 78.57% (22/28), 0% and 0%. There were significant differences among the four pathologies (P < 0.01). The difference between proliferative hemangiomas and involuting hemangiomas was also significant (P < 0.01). The TRAIL mRNA positive rates were 66.67% (11/33), 89.29 (25/28), 0% and 0% respectively. There were also significant differences among the four pathologies (P < 0.01). The difference between proliferative hemangiomas and involuting hemangiomas was also significant (P < 0.01).
Conclusions:
TRAIL could induce endothelial apoptosis and cause regression of hemangiomas.
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