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Updated: Jul 14, 2026

In Vitro Analysis of Myd88-mediated Cellular Immune Response to West Nile Virus Mutant Strain Infection
Published on: November 27, 2014
The molecular basis of antibody-mediated neutralization of West Nile virus
Theodore Oliphant1, Michael S Diamond
1Washington University School of Medicine, Department of Molecular Microbiology, Saint Louis, MO 63110, USA.
Abstract:
The study of the interaction between the West Nile virus envelope protein and monoclonal antibodies has provided insight into the molecular mechanisms of neutralization. Structural studies have identified an epitope on the lateral ridge of domain III of the West Nile virus E protein that is recognized by antibodies with the strongest neutralizing activity in vitro and in vivo. Antibodies that bind to this epitope are particularly inhibitory because they block infection at a post-attachment step and at concentrations that result in a low occupancy of the available sites on the virion.
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