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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
Published on: October 22, 2014
Fibromuscular dysplasia
Pierre-François Plouin1, Jérôme Perdu, Agnès La Batide-Alanore
1Hôpital Européen Georges Pompidou, AP-HP, Université Paris Descartes, Faculté de Médecine, INSERM Unit 772, Collège de France, Paris, France. pierre-francois.plouin@egp.aphp.fr
Orphanet Journal of Rare Diseases
|June 9, 2007
Summary
Fibromuscular dysplasia (FMD) affects renal and carotid arteries, often presenting as renovascular hypertension or cervicocranial complications. Diagnosis involves imaging, with management focusing on blood pressure control and interventions for severe cases.
Area of Science:
- Vascular Medicine
- Arterial Diseases
- Radiology
Background:
- Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory arterial disease.
- It primarily affects the renal and carotid arteries, with varying prevalence rates.
- Histological and angiographic classifications define subtypes like intimal, medial, perimedial, multifocal, and tubular.
Purpose of the Study:
- To summarize the key aspects of fibromuscular dysplasia.
- To detail its common manifestations, diagnostic approaches, and management strategies.
- To highlight FMD as a potential systemic arterial disease.
Main Methods:
- Review of existing literature on fibromuscular dysplasia.
- Analysis of diagnostic modalities including ultrasonography, MRA, CTA, and catheter angiography.
- Examination of treatment options for renal artery and cervicocranial FMD.
Main Results:
- Renovascular hypertension is the most common manifestation of renal artery FMD.
- Cervicocranial FMD can lead to dissection, stroke, or aneurysms.
- The 'string-of-beads' appearance is characteristic of medial FMD on angiography.
- FMD is suggested to be a systemic disease with potential familial links.
Conclusions:
- FMD requires accurate diagnosis through various imaging techniques.
- Management strategies are tailored to the affected arteries and clinical presentation.
- While often slow-progressing, FMD necessitates ongoing monitoring and appropriate therapeutic interventions.
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