Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A within-subject cross-over trial comparing the acute effects of vaporized delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol in healthy adults.

Drug and alcohol dependence·2025

Same author

Characterization of a novel oronasal-restricted nicotine vaping self-administration model in mice.

Neuropharmacology·2025

Same author

Evaluation of the long-term stability of select phenylacetylindole, cycloalkylindole, quinolinyl, and carboxamide synthetic cannabinoids using LC-MS-MS.

Journal of analytical toxicology·2023

Same author

The Role of Morphine-Induced Impairment of Intestinal Epithelial Antibacterial Activity in Dysbiosis and its Impact on the Microbiota-Gut-Brain Axis.

Research square·2023

Same author

Thermal antinociceptive responses to alcohol in DBA/2J and C57BL/6J inbred male and female mouse strains.

Behavioural brain research·2022

Same author

A Participatory Science Approach to Evaluating Factors Associated with the Occurrence of Metals and PFAS in Guatemala City Tap Water.

International journal of environmental research and public health·2022

Search research articles

Related Experiment Video

Updated: Jul 14, 2026

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models

Published on: May 3, 2017

Postmortem memantine concentrations.

Nichole Bynum¹, Justin Poklis, Diana Garside

¹Office of the Chief Medical Examiner, Chapel Hill, North Carolina, USA.

Journal of Analytical Toxicology

|June 9, 2007

Summary

This study reports postmortem concentrations of memantine, a medication for Alzheimer's Disease, in biological samples. Findings aid future toxicological interpretations of memantine levels in suspicious deaths.

Area of Science:

Forensic Toxicology
Pharmacology
Neuroscience

Background:

Alzheimer's Disease (AD) treatment involves medications like memantine.
Accurate postmortem toxicological analysis is crucial for legal and medical investigations.
Establishing reference ranges for drugs in postmortem samples is essential.

Observation:

Memantine concentrations were measured in postmortem fluid and tissue samples.
Analysis involved liquid-liquid extraction and gas chromatography-mass spectrometry (GC-MS).
Data from one suspicious death and three incidental findings were analyzed.

Findings:

Blood memantine concentrations ranged from 0.03 to 1.8 mg/L.
Liver memantine concentration was found to be 6.1 mg/kg.

More Related Videos

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Published on: May 12, 2018

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

Related Experiment Videos

Last Updated: Jul 14, 2026

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models

Published on: May 3, 2017

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Published on: May 12, 2018

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

The study details the methodology for memantine detection in biological matrices.

Implications:

Provides critical reference data for memantine in forensic toxicology.
Aids in the interpretation of memantine levels in postmortem investigations.
Supports accurate assessment in cases involving Alzheimer's Disease medication.