Platelet aggregation abnormalities in patients with recurrent fetal losses
Related Experiment Video
Updated: Jul 14, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
Cengiz Beyan1, Kürşat Kaptan, Ahmet Ifran
1Department of Hematology, Gulhane Military Medical Academy, Etlik, 06010 Ankara, Turkey. cbeyan@yahoo.com
Introduction:
There are some studies reporting that platelets might have a role in cases with recurrent fetal losses. The aim of this study is to evaluate the importance of platelet aggregation abnormalities in this patient group.
Materials And Methods:
In this study, platelet aggregation abnormalities were compared in 56 cases with recurrent fetal losses (29 of these 56 patients have >or=3 losses) and in 33 healthy female controls with no previous history of fetal loss. Platelet aggregation studies were performed with optical turbidometric method by using ADP (5 microM), collagen (0.2 mg/ml) and epinephrine (10 microM).
Results:
We did not find any statistically significant difference between patient (56 cases with >or=2 fetal losses and 29 of them with >or=3 fetal losses) and control groups for platelet aggregation abnormalities.
Conclusions:
The data we have obtained suggest that severe platelet aggregation abnormalities are not the rule in patients with recurrent fetal losses.
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