[Neuroendocrine carcinoma of the skin]

The neuroendocrine carcinoma of the skin (NCS) is an uncommon disease, having been described about 400 cases in world literature. Two cases of NCS in a 52-year-old woman and in a 44-year-old man are reported; their histogenesis is still uncertain. It is advisable a wide cutaneous excision of the neoplasm extending 2-3 cm. over its macroscopic borders, in order to decrease the incidence of local recurrences, reaching 33% in some reports; when regional nodes are involved a lymphadenectomy is recommended. The authors also recommend a prophylactic radiotherapy of locoregional node chains, because of the high radiosensitivity of these tumors.