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Related Experiment Videos

Covert bacteriuria: long term follow up.

V K Aggarwal1, K Verrier Jones, A W Asscher

  • 1Department of Child Health, Cardiff Royal Infirmary.

Archives of Disease in Childhood
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

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Covert bacteriuria in schoolgirls does not impact final kidney length, but early kidney scarring can lead to reduced renal length. Treatment for bacteriuria did not affect outcomes.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Infectious Diseases

Background:

  • Covert bacteriuria, a urinary tract infection without symptoms, is common in school-aged girls.
  • Long-term consequences of untreated covert bacteriuria, particularly on kidney health, require further investigation.
  • Vesicoureteric reflux and reflux nephropathy are known risk factors for kidney damage.

Purpose of the Study:

  • To evaluate the long-term effects of covert bacteriuria on renal length and scarring in schoolgirls.
  • To determine the influence of treatment, vesicoureteric reflux, and initial kidney scarring on renal outcomes.
  • To assess the progression of kidney scarring in girls with and without intervention.

Main Methods:

  • A longitudinal prospective study followed 58 schoolgirls with covert bacteriuria for 8.8 to 13.5 years.

Related Experiment Videos

  • Intravenous urography was performed at the start and end of the follow-up period.
  • Girls were randomly assigned to receive intermittent treatment for covert bacteriuria or no treatment for the first four years.

    • Main Results:

    • No new kidney scars developed in girls with initially normal kidneys.
    • In girls with reflux nephropathy, existing scars progressed in three kidneys, and new scars developed in two.
    • Final renal length was not significantly influenced by vesicoureteric reflux or treatment.
    • Reduced renal length at final assessment was associated with the presence of kidney scarring at initial assessment.

    Conclusions:

    • Early kidney scarring, not covert bacteriuria itself or its treatment, is linked to reduced final renal length.
    • While covert bacteriuria treatment did not alter final renal length, careful monitoring for scarring progression is crucial in affected girls.
    • The study highlights the importance of early detection and management of kidney scarring in pediatric urinary tract infections.