Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predicting early renal allograft function using clinical variables.

Jason Moore1, Kay Tan, Paul Cockwell

  • 1Department of Renal Transplantation, University Hospital Birmingham, Edgbaston, Birmingham, B15 2TH, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|June 9, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of multiple long-term conditions on mortality, progression to kidney failure and health-related quality of life among people with chronic kidney disease: a multicentre cohort study (NURTuRE-CKD).

Annals of medicine·2026
Same author

Clinical practice recommendations for the diagnosis and management of nephropathic cystinosis.

Nature reviews. Nephrology·2026
Same author

"They are nae worrying about it… so …what's the point in asking?": A qualitative study of candidacy for early CKD care in areas of multiple deprivation.

BMC nephrology·2026
Same author

Green extraction of RuBisCO-rich leaf protein for sustainable food systems: process efficiency, functional quality, and sustainability assessment.

Food chemistry·2026
Same author

Primary care pharmacy technicians as medication access experts: A new era in primary care.

Journal of the American Pharmacists Association : JAPhA·2026
Same author

A new self-management engagement scale for haemodialysis patients (PRIESM CKD-HD): development and validation.

Clinical kidney journal·2026
Same journal

Effect of Semaglutide on Measured vs Estimated Glomerular Filtration Rate.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Beyond Diffusion and Convection: Is Adsorption the Third Dimension of Dialysis?

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Pivotal Clinical Trials in C3 Glomerulopathy: answers and remaining uncertainties.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Urinary protein vs albumin for assessing kidney failure risk in chronic kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Systolic blood pressure and albuminuria reduction mediate cardiovascular benefits of finerenone in T2 diabetes and CKD.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Bortezomib-Cyclophosphamide-Dexamethasone versus Rituximab in PGNMID.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
See all related articles

Clinical variables moderately predict early renal transplant function, including delayed graft function (DGF). While useful, caution is advised before changing patient management based solely on these scores.

Area of Science:

  • Nephrology
  • Transplantation immunology
  • Clinical prediction modeling

Background:

  • Suboptimal early graft function is a significant challenge in renal transplantation.
  • Delayed graft function (DGF), requiring post-operative dialysis, is a key indicator, but other forms of suboptimal function are less studied.

Purpose of the Study:

  • To evaluate the predictive ability of clinical variables and established scoring systems for suboptimal early renal allograft function.
  • To assess prediction for various definitions of suboptimal function, including DGF, DGF duration, and creatinine levels.

Main Methods:

  • Analysis of clinical data from 217 renal transplant recipients on ciclosporin-based immunosuppression.
  • Multiple regression and receiver operating characteristic (ROC) curve analyses were used.

Related Experiment Videos

  • Evaluated individual clinical variables and three scoring systems: US Renal Database System (USRDS), deceased donor score (DDS), and expanded criteria donor (ECD) criteria.

    • Main Results:

    • Donor age, BMI, hypertension, donation after cardiac death, recipient ethnicity, recipient weight, and cold ischemic time were associated with early graft function (P<=0.05).
    • All tested scoring systems showed associations with early graft function; only the USRDS score remained significant in the regression model.
    • The USRDS score demonstrated moderate predictive utility for DGF, with improved accuracy at extreme scores (e.g., specificity 95%, PPV 73% for score >=150).

    Conclusions:

    • Clinical variables and scoring systems offer moderate predictive value for early renal allograft function.
    • While potentially useful in practice, these tools should be used cautiously, and management decisions should not rely solely upon them.