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[Study on the distribution of Y chromosome haplogroups in Sichuan Han population]
Ming-yi Ma1, Yuan Yang, Cui-ying Xiao
1Department of Medical Genetics, West China Hospital, Sichuan University, Division of Human Morbids Genomics, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, 610041 PR China.
Objective:
To investigate the distribution characteristics of Y chromosome haplogroups in Sichuan Han population.
Methods:
Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), denatured high performance liquid chromatography (DHPLC) and DNA sequencing methods, 18 Y-chromosome bialletic markers were detected to type Y chromosome haplogroups in 341 unselected men from Sichuan Han population.
Results:
A total of 14 haplogroups were observed, in which haplogroups H2 and H4 were identified for the first time in Sichuan population, and haplogroups H14 and N* were found firstly in Chinese. There was a significant frequency difference of Y haplogroups between Sichuan Han population and Southern Han population.
Conclusion:
More comprehensive frequency distribution data of Y chromosome haplogroups are obtained in Sichuan Han population, which would be helpful for understanding the association of Y chromosome background and the susceptibility to male specific diseases such as spermatogenic failure, prostate cancer, testical cancer and so on in present population.
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