Prediction of drug solubility in water-propylene glycol mixtures using Jouyban-Acree model
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Updated: Jul 14, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
1Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ajouyban@hotmail.com
Abstract:
A trained version of the Jouyban-Acree model was presented to predict drug solubility in water-propylene glycol mixtures at various temperatures. The model is able to predict the solubility in various solubility units and requires the experimental solubility of a solute in mono-solvent systems. The mean percentage deviation (MPD) of predicted solubilities was computed to show the accuracy of the predicted data and 24% was found as the average MPD for 27 data sets studied. The proposed model enables the researchers to predict solubiliy in water-propylene glycol mixtures at various temperatures and reduces the number of required experimental data from five to two points.
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