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Altered oxidant-antioxidant status in non-obese men with moderate essential hypertension

H Nandeesha1, V Sathiyapriya, Zachariah Bobby

  • 1Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Indian Journal of Medical Sciences
|June 15, 2007
PubMed

Insights

Early-stage hypertension in men shows an altered oxidant-antioxidant balance, with increased protein carbonyl and glutathione peroxidase, and decreased catalase and reduced glutathione. This suggests oxidative stress plays a role in hypertension development.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Oxidative Stress Research

Background:

  • Limited clinical data exists on oxidant-antioxidant imbalance in early-stage hypertension among men.
  • Experimental evidence suggests a link between oxidative stress and hypertension.

Purpose of the Study:

  • To investigate oxidative status and antioxidant enzyme activities in males diagnosed with stage I essential hypertension.
  • To compare biochemical markers of oxidative stress between hypertensive and normotensive men.

Main Methods:

  • Cross-sectional study involving 30 men with stage I essential hypertension and 21 normotensive controls.
  • Assessed plasma levels of protein carbonyl, reduced glutathione (GSH), glutathione peroxidase (GPx), catalase, and fasting glucose.
  • Statistical analysis included Student's t-test and linear regression.

Main Results:

  • Hypertensive men exhibited significantly elevated plasma protein carbonyl and GPx levels compared to normotensive controls.
  • Significantly reduced levels of catalase and GSH were observed in the hypertensive group.
  • A significant negative correlation was found between GPx and catalase in hypertensive subjects.

Conclusions:

  • Early-stage essential hypertension in non-obese men is associated with a distinct alteration in the oxidant-antioxidant status.
  • Findings suggest increased oxidative stress and compromised antioxidant defense mechanisms in the early phase of hypertension.
Abstract

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