Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synaptic P2X7 receptor regenerative-loop hypothesis for depression.

Maxwell R Bennett1

  • 1Brain and Mind Research Institute, University of Sydney, Camperdown, Australia. maxb@physiol.usyd.edu.au

The Australian and New Zealand Journal of Psychiatry
|June 15, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ketamine and Zinc: Treatment of Anorexia Nervosa Via Dual NMDA Receptor Modulation.

CNS drugs·2023
Same author

Electrophysiological phenotypes of suicidality predict prolonged response to oral ketamine treatment.

Progress in neuro-psychopharmacology & biological psychiatry·2022
Same author

Six-week oral ketamine treatment for chronic suicidality is associated with increased grey matter volume.

Psychiatry research. Neuroimaging·2021
Same author

Quantitative relations between BOLD responses, cortical energetics and impulse firing across cortical depth.

The European journal of neuroscience·2021
Same author

P2X<sub>7</sub> receptor knockout mice display less aggressive biting behaviour correlating with increased brain activation in the piriform cortex.

Neuroscience letters·2019
Same author

A model of amygdala function following plastic changes at specific synapses during extinction.

Neurobiology of stress·2019
Same journal

Letter to the Editor regarding 'Middle childhood profiles of social-emotional competencies and difficulties differentiate risk of health service presentations with adolescent mental disorders'.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Diagnostic complexity and comorbidity: Implications for identification, outcomes, health care and involuntary treatment.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Defining and measuring psychosocial disability in Australia: Assessment of national surveys and administrative datasets.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Academic performance in children of mothers with perinatal depressive disorder.

The Australian and New Zealand journal of psychiatry·2026
Same journal

The Multisensory Hallucinations Schedule to assess hallucinations across multiple sensory modalities in psychosis: A pilot validation study.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Student wellbeing supports in Australian and New Zealand medical schools: A post-guidance snapshot from a 14-institution survey.

The Australian and New Zealand journal of psychiatry·2026
See all related articles

The P2X7 receptor, linked to mood disorders, may function in a regenerative loop at synapses, influencing neural network states. Gene variations or infections affecting this loop could increase vulnerability to depression and bipolar disorder.

Area of Science:

  • Neurobiology
  • Synaptic Transmission
  • Molecular Psychiatry

Background:

  • Peripheral synapses releasing adenosine 5'-triphosphate (ATP) were discovered 45 years ago.
  • The P2X7 receptor is implicated in major depression and bipolar disorder.
  • The hippocampus is a key neural network affected by these disorders.

Purpose of the Study:

  • To explore mechanisms linking P2X7 gene polymorphisms to neural network function.
  • To hypothesize the role of P2X7 receptors in synaptic transmission within the hippocampus.

Main Methods:

  • Selective review of neurobiological literature on P2X7 receptor function.
  • Analysis of P2X7 receptor location and function at synapses, astrocytes, and microglia.
  • Consideration of P2X7 receptor involvement in regenerative loops and cytokine release.

Related Experiment Videos

Main Results:

  • P2X7 receptors may participate in a regenerative loop at glutamatergic synapses, increasing glutamate and ATP release.
  • Synaptic ATP and glutamate can activate microglia, releasing tumor necrosis factor-alpha (TNF-alpha) to enhance postsynaptic AMPA receptors.
  • Infections can alter neural network states by modulating P2X7 and toll-like receptors, affecting cytokine release and AMPA receptor levels.

Conclusions:

  • Polymorphisms in the P2X7 gene can alter synaptic function and neural network states.
  • These alterations may contribute to the vulnerability to mood disorders like depression and bipolar disorder.
  • The P2X7 receptor system offers potential targets for understanding and treating mood disorders.