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Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut
Published on: January 31, 2025
Polyamines and the intestinal tract
Nikolaus Seiler1, Francis Raul
1INSERM U682, Université Louis Pasteur EA3430, Faculty of Medicine, Laboratory of Nutritional Cancer Prevention, IRCAD, Strasbourg, France.
Critical Reviews in Clinical Laboratory Sciences
|June 15, 2007
Summary
Polyamines are vital for intestinal cell growth and repair. While targeting polyamine metabolism for cancer therapy has failed, inhibiting ornithine decarboxylase shows promise for preventing familial adenomatous polyposis.
Area of Science:
- Cell biology
- Gastroenterology
- Biochemistry
Background:
- Intestinal mucosal cells exhibit rapid turnover, necessitating high polyamine levels for growth and differentiation.
- Polyamines play crucial roles in maintaining gut function, mucosal maturation, and injury repair.
- Understanding polyamine metabolism is key to studying physiological growth and disease.
Purpose of the Study:
- To review the role of polyamines in intestinal mucosal cells.
- To discuss polyamine metabolism, regulation, and function in the gut.
- To evaluate polyamine metabolism as a therapeutic and chemopreventive target in gastrointestinal diseases.
Main Methods:
- Review of existing literature on polyamine metabolism and function in the intestinal tract.
- Discussion of the effects of polyamine depletion and repletion using (D,L)-2-(difluoromethyl)ornithine.
- Analysis of polyamine metabolism's role in normal and neoplastic growth, including cancer therapeutics and chemoprevention.
Main Results:
- Polyamines are essential for intestinal mucosal integrity, maturation, and repair processes.
- (D,L)-2-(difluoromethyl)ornithine repletion enhanced understanding of polyamine involvement in normal and neoplastic growth regulation.
- Targeting polyamine metabolism for cancer therapy has not yet yielded success.
Conclusions:
- Selective inactivation of ornithine decarboxylase is a potential chemopreventive strategy for familial adenomatous polyposis.
- Ornithine decarboxylase critically regulates the proliferative response of the protooncogene c-myc, independent of its apoptotic response.
- Further research into polyamine pathways may offer new avenues for gastrointestinal disease management.
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