Related Experiment Video
Updated: Jul 14, 2026
08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
Hirsutism and hyperandrogenism associated with hyperreactio luteinalis in a singleton pregnancy: a case report
Stefano Angioni1, Elaine Portoghese, Francesca Milano
1Division of Gynecology, Obstetrics and Pathophysiology of Human Reproduction, Department of Surgery, Maternal-Fetal Medicine, and Imaging, University of Cagliari, Cagliari, Italy. sangioni@yahoo.it
Summary
Hyperreactio luteinalis is a rare pregnancy complication causing high androgen levels and ovarian masses. Conservative management and monitoring are recommended for a healthy mother and baby.
Area of Science:
- Reproductive Endocrinology
- Obstetrics and Gynecology
Background:
- Hyperandrogenism in pregnancy is uncommon, but associated ovarian conditions are more frequent.
- Hyperreactio luteinalis is a rare, benign condition that can present symptomatically similar to ovarian or trophoblastic malignancies.
Observation:
- A 23-year-old pregnant woman at 20 weeks' gestation presented with severe hirsutism and bilateral ovarian masses.
- The patient underwent conservative management with close clinical and ultrasound monitoring.
Findings:
- The final diagnosis was hyperreactio luteinalis, a condition characterized by enlarged lutein cysts of the ovary.
- The patient successfully delivered a healthy female neonate.
Implications:
- Conservative management and vigilant monitoring are the optimal approaches for hyperreactio luteinalis during pregnancy.
- Patient counseling is essential to address concerns regarding the temporary effects of hyperandrogenism on both the mother and the developing fetus.
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