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Updated: Jul 14, 2026
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A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats
Published on: November 6, 2018
Place conditioning in a two- or three-conditioning compartment apparatus: a comparative study with morphine and
Lidia Morales1, Carmen Perez-Garcia, Gonzalo Herradon
1Department of Pharmacology, Technology and Pharmaceutical Development, University San Pablo CEU, Spain.
Addiction Biology
|June 15, 2007
Summary
The number of compartments in a place conditioning apparatus affects opioid aversion studies. A two-compartment setup showed stronger U-50,488 aversion than a three-compartment setup, suggesting neutral environments reduce sensitivity.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- The place conditioning paradigm is a standard method for assessing the rewarding and aversive properties of drugs.
- Opioid research often utilizes this paradigm to understand drug-induced behavioral changes.
Purpose of the Study:
- To compare the effects of two opioids, morphine and U-50,488, on place conditioning using two- and three-compartment apparatuses.
- To investigate how the number of compartments influences the detection of drug-induced place aversion.
Main Methods:
- Rats underwent three days of daily conditioning sessions, receiving either drug or saline.
- Experimental conditions were identical except for the use of either a two- or three-conditioning compartment apparatus.
- Morphine and U-50,488 were used as the test opioids.
Main Results:
- Morphine-induced place preference was comparable between the two- and three-compartment apparatuses.
- U-50,488-induced place aversion was significantly more pronounced in the two-compartment apparatus.
- The presence of neutral environments in the three-compartment setup appeared to decrease the sensitivity for quantifying place aversion.
Conclusions:
- The design of the place conditioning apparatus, specifically the number of compartments, can impact the observed behavioral effects of certain drugs.
- A two-compartment apparatus may offer increased sensitivity for detecting place aversion compared to a three-compartment setup.
- Neutral environments in conditioning paradigms may attenuate the detection of aversive drug effects.
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