Genetics of the immune response to infectious pathogens

In this selective review of the recent literature in the field of genetically determined host resistance to infection, we highlight five areas in which research is directed towards the search for proteins encoded by genes that function to maintain a 'resistant' phenotype in the face of challenge by a variety of pathogenic organisms. In particular, we discuss newly described genes that may regulate host resistance, newly described functions of genes previously identified, the reverse genetics approach to cloning an elusive gene, a direct genetics approach to a similar problem, and the role of the major histocompatibility complex in regulating our ability to resist challenge by infectious organisms.