Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HIV types and testing.

A G Dalgleish1

  • 1London Hospital Medical College, UK.

Current Opinion in Immunology
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

New human and simian immunodeficiency viruses (HIVs and SIVs) have been discovered, challenging existing classifications. Advanced diagnostic assays, including polymerase chain reaction and combination enzyme-linked immunosorbent assays, are now available for improved detection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Gemcitabine based chemotherapy on the immunogenicity of pancreatic tumour cells and T-cells.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2020
Same author

Gemcitabine alters the proteasome composition and immunopeptidome of tumour cells.

Oncoimmunology·2018
Same author

The T4 molecule: function and structure.

Immunology today·2014
Same author

B cells in the pathogenesis of AIDS.

Immunology today·2014
Same author

Treatment patterns, outcomes, and resource utilization of patients with metastatic melanoma in the U.K.: the MELODY study.

The British journal of dermatology·2013
Same author

Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis.

British journal of cancer·2012
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Area of Science:

  • Virology
  • Immunology
  • Molecular Biology

Background:

  • Recent discovery of novel viral isolates not aligning with established Human Immunodeficiency Virus (HIV) types 1 and 2, or Simian Immunodeficiency Virus (SIV) classifications.
  • Advancements in diagnostic technologies have emerged, including the polymerase chain reaction (PCR) and novel enzyme-linked immunosorbent assays (ELISAs).

Purpose of the Study:

  • To report on the discovery of new viral isolates that challenge existing HIV and SIV categorization.
  • To highlight the development and application of new diagnostic assays for improved viral detection and characterization.

Main Methods:

  • Utilized polymerase chain reaction (PCR) for viral detection and characterization.
  • Developed and employed new combination enzyme-linked immunosorbent assays (ELISAs) for detecting viruses from multiple groups.

Related Experiment Videos

  • Incorporated specific ELISAs utilizing peptides and monoclonal antibodies for targeted viral identification.

    • Main Results:

    • Identified new viral isolates that do not fit established HIV-1, HIV-2, and SIV categories.
    • Demonstrated the capability of new combination ELISAs to detect viruses from two or more groups simultaneously.
    • Showcased the effectiveness of specific ELISAs employing peptides and monoclonal antibodies in viral assays.

    Conclusions:

    • The emergence of new viral isolates necessitates a re-evaluation of current HIV and SIV classification systems.
    • Newly developed diagnostic assays, including PCR and advanced ELISAs, offer enhanced sensitivity and specificity for detecting diverse viral strains.
    • These advancements in detection methods are crucial for accurate diagnosis and understanding the evolving landscape of lentiviruses.