Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases
Related Experiment Video
Updated: Jul 14, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
Kimberly W Raines1, Marcelo G Bonini, Sharon L Campbell
1Department of Biochemistry and Biophysics, University of North Carolina, 530 Mary Ellen Jones Building, Chapel Hill, NC 27599-7260, USA.
Abstract:
The Ras superfamily of small GTPases cycle between inactive GDP-bound and active GTP-bound states to modulate a diverse array of processes involved in cellular growth control. While the basic mechanisms by which GTPase regulatory proteins regulate GTPase substrates have been revealed through numerous studies, detailed studies into the mechanism(s) of free radical-mediated GTPase regulation have only more recently been tackled. This article reviews the mechanism of free radical-mediated GTPase regulation and shows nitric oxide can serve as important regulator of small GTPase proteins (i.e. Ras and RhoA) through protein modifications such as S-nitrosation.
More Related Videos
Related Concept Videos
Nitric Oxide Signaling Pathway
Small GTPases - Ras and Rho
Three regulatory proteins control their activity:
The Ras Gene
Ras is a superfamily...
MAPK Signaling Cascades
Activation and Inactivation of G Proteins
GTPases and their Regulation
Large G-proteins, also known...

