Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transplantation tolerance.

K J Wood1

  • 1University of Oxford, John Radcliffe Hospital, UK.

Current Opinion in Immunology
|October 1, 1991
PubMed
Summary
This summary is machine-generated.

New protocols are advancing kidney transplant tolerance by targeting donor antigens. Research also deepens the understanding of the complex, multi-mechanistic processes involved in achieving long-term transplant acceptance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ex vivo-expanded human CD19<sup>+</sup>TIM-1<sup>+</sup> regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis.

Nature communications·2022
Same author

Quantification of CD4(+) T Cell Alloreactivity and Its Control by Regulatory T Cells Using Time-Lapse Microscopy and Immune Synapse Detection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Demethylation of the TSDR is a marker of squamous cell carcinoma in transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
Same author

Harnessing regulatory T cells for clinical use in transplantation: the end of the beginning.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
Same author

The role of donor-specific HLA alloantibodies in liver transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
Same author

Cross-validation of IFN-γ Elispot assay for measuring alloreactive memory/effector T cell responses in renal transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Area of Science:

  • Immunology
  • Transplantation Science

Background:

  • Developing effective protocols for inducing transplantation tolerance is crucial for improving patient outcomes.
  • Understanding the mechanisms underlying tolerance induction and maintenance is key to refining therapeutic strategies.

Purpose of the Study:

  • To report on recent advancements in experimental protocols for inducing transplantation tolerance.
  • To highlight progress in understanding the in vivo mechanisms of alloantigen tolerance.

Main Methods:

  • Clinical trial data from a protocol targeting kidney donor histocompatibility antigens.
  • In vivo studies investigating the mechanisms of alloantigen tolerance.

Main Results:

  • Encouraging data emerged from a clinical trial for kidney transplant tolerance.

Related Experiment Videos

  • Increased clarity on the multiple mechanisms involved in tolerance induction and maintenance.

    • Conclusions:

    • Recent progress shows promise for novel protocols in achieving transplantation tolerance.
    • The understanding of tolerance mechanisms is evolving, revealing complexity and phase-specific involvement.