Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural aspects of allorecognition.

R Lechler1, G Lombardi

  • 1Royal Postgraduate Medical School, London, UK.

Current Opinion in Immunology
|October 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased prevalence of thyroid autoimmunity in patients successfully treated for Cushing's disease.

Clinical endocrinology·2000
Same author

The effect of quinagolide and cabergoline, two selective dopamine receptor type 2 agonists, in the treatment of prolactinomas.

Clinical endocrinology·2000
Same author

FISH deletion mapping defines a single location for the Y chromosome stature gene, GCY.

Journal of medical genetics·2000
Same author

Antineutrophil cytoplasmic antibodies in inflammatory bowel disease: clinical role and review of the literature.

Diseases of the colon and rectum·2000
Same author

Anergic T cells inhibit the antigen-presenting function of dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)·2000
Same author

Female pseudohermaphroditism and inefficient peak bone mass in an untreated subject affected by 21-hydroxylase congenital adrenal hyperplasia.

Journal of endocrinological investigation·2000

T-cell allorecognition of foreign major histocompatibility molecules is a complex immunological mystery. Recent analyses of major histocompatibility complex structure and function are beginning to reveal its molecular basis.

Area of Science:

  • Immunology
  • Molecular Biology
  • Structural Biology

Background:

  • T-cell allorecognition of foreign major histocompatibility (MHC) molecules is a poorly understood phenomenon in T-cell immunology.
  • Understanding this process is crucial for transplantation and autoimmune disease research.

Purpose of the Study:

  • To elucidate the molecular underpinnings of T-cell allorecognition.
  • To integrate structural and functional insights into MHC products for a clearer understanding of allorecognition.

Main Methods:

  • Structure/function analyses of major histocompatibility complex (MHC) molecules.
  • Application of current knowledge of three-dimensional MHC structures.

Main Results:

  • The study applies advanced MHC structure/function analyses.

Related Experiment Videos

  • Insights into the 3D structure of MHC products are being utilized.

    • Conclusions:

    • The molecular basis of T-cell allorecognition is progressively being uncovered.
    • Integrating structural and functional data provides a pathway to understanding this enigmatic immunological process.