Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Acute Inflammation I: Cellular Phase01:26

Acute Inflammation I: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut serotonin regulates Kupffer cell appetite for drug carriers.

Cell research·2026
Same author

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers.

Nature reviews. Immunology·2026
Same author

Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectin.

The Journal of clinical investigation·2026
Same author

Neutrophils fine-tune the NET effects of activation.

Blood·2025
Same author

P selectin promotes SARS-CoV-2 interactions with platelets and the endothelium.

The Journal of clinical investigation·2025
Same author

Postnatal liver B cell precursors contribute to the establishment of a mature B cell pool in secondary lymphoid organs in mice.

Journal of immunology (Baltimore, Md. : 1950)·2025

Related Experiment Video

Updated: May 11, 2026

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow
11:30

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Published on: January 7, 2015

Modulating leukocyte recruitment in inflammation.

Margaret Kelly1, John M Hwang, Paul Kubes

  • 1Department of Pathology, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada.

The Journal of Allergy and Clinical Immunology
|June 15, 2007
PubMed
Summary

This review details the leukocyte recruitment cascade, focusing on selectins and integrins in inflammation. Understanding these molecular mechanisms offers potential for future therapeutic strategies targeting white blood cell migration.

More Related Videos

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

In Vivo Imaging Uncovers the Migratory Behavior of Leukocytes within the Joints
10:10

In Vivo Imaging Uncovers the Migratory Behavior of Leukocytes within the Joints

Published on: December 9, 2025

Related Experiment Videos

Last Updated: May 11, 2026

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow
11:30

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Published on: January 7, 2015

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

In Vivo Imaging Uncovers the Migratory Behavior of Leukocytes within the Joints
10:10

In Vivo Imaging Uncovers the Migratory Behavior of Leukocytes within the Joints

Published on: December 9, 2025

Area of Science:

  • Immunology
  • Cell Biology
  • Microcirculation Research

Background:

  • Leukocyte recruitment to inflammatory sites is crucial for immune response.
  • The molecular mechanisms governing this process are complex and involve multiple steps.

Purpose of the Study:

  • To summarize the leukocyte recruitment cascade.
  • To highlight the molecular mechanisms, particularly selectins and integrins, involved in leukocyte adhesion and migration.
  • To discuss the implications for asthma and skin contact sensitivity models.

Main Methods:

  • Review of existing literature on leukocyte recruitment.
  • Emphasis on molecular interactions like selectin-ligand and integrin-mediated adhesion.
  • Discussion of cellular processes including rolling, adhesion, crawling, and emigration.

Main Results:

  • Selectins and integrins play pivotal roles in leukocyte rolling and adhesion.
  • Mechanisms of intraluminal crawling and emigration are also significant.
  • These molecular pathways are implicated in eosinophil and lymphocyte recruitment in specific disease models.

Conclusions:

  • Leukocyte recruitment is a tightly regulated cascade involving specific molecular interactions.
  • Understanding these mechanisms provides a basis for developing novel therapeutics.
  • Targeting leukocyte recruitment pathways holds promise for treating inflammatory conditions.