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Updated: Jul 14, 2026
10:51
Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Structure and function of the atypical orphan nuclear receptor small heterodimer partner
Yong-Soo Lee1, Dipanjan Chanda, Jeonggu Sim
1Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, Korea.
International Review of Cytology
|June 15, 2007
Summary
Small heterodimer partner (SHP) is an orphan nuclear receptor regulating metabolic homeostasis. Recent research clarifies SHP
Area of Science:
- Molecular Biology
- Endocrinology
- Genetics
Background:
- Small heterodimer partner (SHP; NROB2) is an orphan nuclear receptor.
- SHP lacks a DNA-binding domain and acts as a transcriptional coregulator.
- SHP plays roles in metabolic homeostasis and physiological functions.
Purpose of the Study:
- To review the current understanding of SHP.
- To discuss SHP structure, expression, and function.
- To highlight SHP's role in metabolic regulation.
Main Methods:
- Literature review of recent advancements in SHP research.
- Analysis of studies on SHP mechanism of action and gene expression.
- Synthesis of findings on SHP's involvement in metabolic homeostasis.
Main Results:
- Significant progress in understanding SHP's mechanism of action.
- Insights into the regulation of SHP gene expression.
- Evidence supporting SHP's diverse roles in metabolic homeostasis.
Conclusions:
- SHP is a key regulator of metabolic homeostasis.
- Further research is needed to fully elucidate SHP's functions.
- SHP represents a potential therapeutic target for metabolic disorders.
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