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Vaccinations

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Alternative early life vaccination programs for companion animals.

¹Merial Research and Development, 254 rue Marcel Mérieux, 69007 Lyon, France. herve.poulet@merial.com

Journal of Comparative Pathology

|June 15, 2007

Summary

Kitten vaccination provides protection against feline parvovirus, but immunity wanes for other diseases over a year. Earlier booster shots may improve protection, and maternally derived antibodies can impact vaccine response.

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Published on: July 31, 2021

Area of Science:

Veterinary immunology
Vaccinology
Feline infectious diseases

Background:

Assessing the duration of immunity following multicomponent vaccination in kittens.
Investigating the impact of maternally derived antibodies (MDA) on kitten vaccine efficacy.

Purpose of the Study:

To evaluate the protective immunity conferred by a multicomponent kitten vaccine at 4 weeks and 1 year post-vaccination.
To determine the influence of MDA on the serological response to vaccination in kittens.

Main Methods:

Experimental challenge study using specific pathogen-free kittens vaccinated with a non-adjuvanted multicomponent vaccine.
Kittens were challenged with feline parvovirus, feline herpesvirus, feline calicivirus, and Chlamydophila felis at different time points.
Serum antibody titres were measured to assess the impact of MDA on vaccination responses.

Main Results:

Complete protection against feline parvovirus was observed at both 4 weeks and 1 year post-vaccination.
Protection against feline herpesvirus, feline calicivirus, and Chlamydophila felis diminished by 1 year post-vaccination.
Maternally derived antibodies showed heterogeneity and could neutralize serological responses, particularly in younger kittens.

Conclusions:

A decline in protective immunity suggests that the first booster vaccine may need earlier administration (4-6 months of age).
Maternally derived antibodies can interfere with kitten vaccination responses, supporting later primary vaccination series completion (16 weeks of age).