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Olmesartan blocks advanced glycation end products (AGEs)-induced angiogenesis in vitro by suppressing receptor for

Sho-ichi Yamagishi1, Takanori Matsui, Kazuo Nakamura

  • 1Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. shoichi@med.kurume-u.ac.jp

Microvascular Research
|June 15, 2007
PubMed

Insights

Olmesartan, an angiotensin II receptor blocker, inhibits angiogenesis in diabetic retinopathy by suppressing RAGE expression. This suggests olmesartan may protect against proliferative diabetic retinopathy by reducing the effects of advanced glycation end products.

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Pharmacology

Background:

  • Advanced glycation end products (AGEs) and their receptor (RAGE) interaction promote angiogenesis via vascular endothelial growth factor (VEGF).
  • The AGEs-RAGE system and renin-angiotensin system crosstalk are implicated in proliferative diabetic retinopathy (PDR) pathogenesis.

Purpose of the Study:

  • To investigate if olmesartan, an angiotensin II type 1 receptor blocker, inhibits AGEs-induced angiogenesis in vitro.
  • To determine if olmesartan suppresses NF-kappaB-mediated RAGE expression.

Main Methods:

  • Cultured microvascular endothelial cells (ECs) were treated with AGEs and olmesartan.
  • Assessed NF-kappaB promoter activity, RAGE gene expression, and VEGF mRNA levels.
  • Measured DNA synthesis in ECs.

Main Results:

  • Olmesartan significantly inhibited AGEs-induced NF-kappaB promoter activity and RAGE gene expression in ECs.
  • Olmesartan blocked AGEs-induced up-regulation of VEGF mRNA and subsequent DNA synthesis.
  • Demonstrated olmesartan's inhibition of AGEs signaling to angiogenesis via RAGE suppression.

Conclusions:

  • Olmesartan inhibits AGEs-induced angiogenesis by suppressing RAGE expression in endothelial cells.
  • Blockade of the renin-angiotensin system by olmesartan may offer protection against PDR.
  • Olmesartan attenuates AGEs deleterious effects through RAGE down-regulation.

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