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Updated: Jul 14, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Postpartum-onset major depression is associated with personality disorders
Cemal Akman1, Faruk Uguz, Nazmiye Kaya
1Department of Psychiatry, Meram Faculty of Medicine, Selcuk University, Meram Konya 42080, Turkey.
Postpartum-onset major depression (PPMD) affects 6.3% of new mothers. Women with avoidant, dependent, and obsessive-compulsive personality disorders face a higher risk of developing PPMD.
Area of Science:
- Psychiatry
- Obstetrics
- Mental Health
Background:
- Postpartum-onset major depression (PPMD) is a significant concern for new mothers.
- Understanding risk factors is crucial for timely intervention and support.
Purpose of the Study:
- To determine the incidence of PPMD.
- To identify sociodemographic, obstetric, and personality disorder correlates of PPMD.
Main Methods:
- The study involved 302 women interviewed at childbirth and 6 weeks postpartum.
- Diagnoses of major depression and personality disorders used standardized clinical interviews.
- Structured Clinical Interview for DSM-IV and DSM-III-R Personality Disorders were utilized.
Main Results:
- The incidence of new-onset PPMD was 6.3% within 6 weeks postpartum.
- PPMD was not associated with common sociodemographic or obstetric factors.
- Higher frequencies of avoidant, dependent, and obsessive-compulsive personality disorders were observed in women with PPMD.
Conclusions:
- Avoidant, dependent, and obsessive-compulsive personality disorders are independent predictors of PPMD.
- Childbearing women with these personality disorders have an elevated risk for postpartum depression.
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