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Related Experiment Video

Updated: Jul 14, 2026

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation
04:48

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Published on: April 18, 2025

Running is rewarding and antidepressive.

Stefan Brené1, Astrid Bjørnebekk, Elin Aberg

  • 1Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Karolinska University Hospital, Huddinge, S-141 86 Stockholm, Sweden. stefan.brene@ki.se

Physiology & Behavior
|June 15, 2007
PubMed
Summary

Both addictive drugs and exercise activate brain reward pathways. Exercise, unlike drugs, also benefits the hippocampus, offering antidepressant effects.

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Area of Science:

  • Neuroscience
  • Neurobiology
  • Behavioral Science

Background:

  • Natural behaviors like eating and exercise activate brain reward pathways, reinforcing engagement.
  • Drugs of abuse strongly activate these pathways, leading to addiction.
  • Both behaviors and drugs impact brain regions beyond reward centers, such as the hippocampus.

Purpose of the Study:

  • To compare neurochemical and functional brain changes induced by addictive drugs versus exercise.
  • To focus on the effects on brain reward pathways and the hippocampus.

Main Methods:

  • Comparative analysis of neurochemical changes.
  • Functional brain assessments.
  • Focus on reward pathways and hippocampal function.

Main Results:

  • Addictive drugs and exercise both activate reward pathways.
  • Exercise uniquely promotes neurogenesis in the hippocampus.
  • Exercise demonstrates antidepressant effects in animal models and humans.

Conclusions:

  • While both drugs and exercise activate reward systems, exercise offers additional neurobiological benefits.
  • Exercise-induced hippocampal changes may underlie its antidepressant properties.
  • Understanding these differences is crucial for addiction research and therapeutic strategies.