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Published on: December 6, 2016
The Apnea Positive Pressure Long-term Efficacy Study (APPLES): rationale, design, methods, and procedures
Clete A Kushida1, Deborah A Nichols, Stuart F Quan
1Stanford Universit)y, Stanfbrd, CA, USA. clete@stanford.edu
Summary
This study investigates the long-term effects of continuous positive airway pressure (CPAP) therapy on cognitive function and mood in patients with obstructive sleep apnea. The Apnea Positive Pressure Long-term Efficacy Study (APPLES) uses a rigorous trial design to assess treatment durability.
Area of Science:
- Sleep Medicine
- Neuroscience
- Pulmonology
Background:
- Obstructive sleep apnea (OSA) is a common sleep disorder associated with significant health consequences.
- Continuous positive airway pressure (CPAP) is the primary treatment for moderate to severe OSA.
- The long-term effects of CPAP on neurocognitive function, mood, and quality of life in OSA patients require further investigation.
Purpose of the Study:
- To evaluate the sustained impact of long-term CPAP therapy on neurocognitive function in individuals with obstructive sleep apnea.
- To assess the durability of CPAP's effects on mood, sleepiness, and overall quality of life in OSA patients.
- To determine the time course and magnitude of CPAP's benefits in a large, well-characterized OSA cohort.
Main Methods:
- A randomized, double-blinded, sham-controlled, multicenter trial involving 1100 participants with obstructive sleep apnea.
- Participants were assigned to receive either active CPAP or sham (subtherapeutic) CPAP therapy.
- Neurocognitive function, mood, sleepiness, and quality of life were assessed using a comprehensive battery of conventional and novel tests.
Main Results:
- The study is designed to provide robust data on the efficacy of long-term CPAP therapy.
- Results will elucidate the extent and duration of CPAP's influence on various patient-reported and objectively measured outcomes.
- The findings will contribute to understanding the neurocognitive and psychological benefits of sustained CPAP use in OSA.
Conclusions:
- The Apnea Positive Pressure Long-term Efficacy Study (APPLES) is a comprehensive trial designed to rigorously assess the long-term efficacy of CPAP for obstructive sleep apnea.
- This study aims to provide definitive evidence regarding the benefits of CPAP on neurocognitive function, mood, and quality of life.
- The findings are expected to inform clinical practice and guidelines for managing obstructive sleep apnea.
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