Related Experiment Video

Updated: Jun 11, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

[Childhood chronic fatigue syndrome]

Teruhisa Miike1

  • 1Department of Child Development, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Graduate School.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 15, 2007
PubMed

Insights

Childhood Chronic Fatigue Syndrome (CCFS) affects 3-5% of youth, causing fatigue and confusion. Key symptoms include sleep issues, fatigability, learning difficulties, and immune problems, requiring treatment for circadian rhythms and energy.

Area of Science:

  • Pediatrics
  • Neurology
  • Immunology

Context:

  • Childhood Chronic Fatigue Syndrome (CCFS) is a complex condition affecting 3-5% of children and adolescents.
  • Characterized by debilitating fatigue and confusion lasting over 30 days.

Purpose:

  • To outline the key symptoms, diagnostic criteria, and potential treatment approaches for CCFS.
  • To highlight the specific physiological abnormalities observed in pediatric patients.

Summary:

  • CCFS presents with four main symptoms: sleep disorders, easy fatigability, disturbed learning/memorization, and immunological problems.
  • Diagnostic criteria were established by a Japanese research group in 2004.
  • Abnormalities in serum pyruvic acid, OGTT, body temperature rhythm, hormonal secretion, and cerebral blood flow are noted.

Impact:

  • Provides a foundational understanding of CCFS in pediatric populations.
  • Informs diagnostic approaches and potential therapeutic targets for improving patient outcomes.
  • Highlights the need for further research into the underlying mechanisms and effective treatments for CCFS.

More Related Videos

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

Related Concept Videos

Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...