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Updated: Jul 14, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
Published on: March 1, 2022
[Bone metabolism: molecular mechanisms]
1Abteilung für Innere Medizin und Rheumatologie, Justus-Liebig-Universität, Giessen.
Abstract:
In order to accommodate individual load, the skeletal system is in a continual state of change. Bone metabolism guarantees optimal bone structure. The osteoblasts are responsible for the synthesis and the osteoclasts for resorption of the bone. A finely adjusted interplay between molecular mechanisms leads, via cytokines, hormones and growth factors, to an homeostasis in bone metabolism. Disturbances of this process lead via increased bone resorption to osteoporosis, and via increased synthesis to osteopetrosis. This contribution describes the known molecular mechanisms in this remodelling process.
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