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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Related Experiment Video

Updated: Jul 14, 2026

Generation of Plasmid Vectors Expressing FLAG-tagged Proteins Under the Regulation of Human Elongation Factor-1α Promoter Using Gibson Assembly

Generation of Plasmid Vectors Expressing FLAG-tagged Proteins Under the Regulation of Human Elongation Factor-1α Promoter Using Gibson Assembly

Published on: February 9, 2015

Plasmalogen assembly: a key flavoenzyme.

Dale E Edmondson

Structure (London, England : 1993)

|June 15, 2007

Summary

Alkyldihydroxyacetonephosphate synthase (ADPS) is a peroxisomal flavoenzyme. Its structural properties reveal how it converts ester to ether linkages in plasmologen biosynthesis.

Area of Science:

Biochemistry
Structural Biology
Enzymology

Background:

Plasmologen biosynthesis is crucial for cellular function.
Alkyldihydroxyacetonephosphate synthase (ADPS) plays a key role in this pathway.
Understanding ADPS mechanism is vital for metabolic research.

Discussion:

The study details the structural properties of ADPS.
These properties elucidate the enzyme's catalytic mechanism.
The nonredox reaction involves ester to ether conversion.

Key Insights:

Structural insights into ADPS function.
Mechanism of nonredox catalysis in plasmologen synthesis.
Flavoenzyme activity in peroxisomal pathways.

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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

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Published on: August 14, 2019

Related Experiment Videos

Last Updated: Jul 14, 2026

Generation of Plasmid Vectors Expressing FLAG-tagged Proteins Under the Regulation of Human Elongation Factor-1α Promoter Using Gibson Assembly

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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

Outlook:

Further research into ADPS and related enzymes.
Potential therapeutic targets in metabolic disorders.
Applications in synthetic biology and enzyme engineering.