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Updated: Jul 14, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Androgens and prostate cancer risk: a prospective study
Sara Wirén1, Tanja Stocks, Sabina Rinaldi
1Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
The Prostate
|June 15, 2007
Summary
This study found no significant link between androgen levels, including testosterone, and prostate cancer risk in a population-based cohort. Androgen levels did not predict overall prostate cancer or aggressive tumor development.
Area of Science:
- Endocrinology
- Oncology
- Epidemiology
Background:
- Androgens are linked to prostate cancer development.
- Previous studies show mixed results on androgen levels and prostate cancer risk.
- Some research suggests testosterone may influence tumor aggressiveness.
Purpose of the Study:
- To investigate the association between circulating androgen levels and prostate cancer risk.
- To determine if androgen levels correlate with tumor aggressiveness.
Main Methods:
- Prospective nested case-control study.
- Measured plasma levels of total testosterone, androstanediol glucuronide (A-diol-g), and sex hormone binding globulin (SHBG).
- Calculated estimated free testosterone levels in 392 cases and 392 controls.
Main Results:
- No significant associations were found between any studied androgen levels and overall prostate cancer risk.
- Subgroup analyses by tumor aggressiveness also showed no significant associations.
- Odds ratios for top vs. bottom quartiles of hormones indicated no clear trend with prostate cancer risk.
Conclusions:
- Circulating androgen levels are not significantly associated with prostate cancer risk in this population.
- Findings suggest androgens may not be a primary risk factor for prostate cancer in this cohort.
- Further research may be needed to clarify the role of androgens in prostate cancer.
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