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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

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Related Experiment Video

Updated: Jul 14, 2026

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

Imaging genetics for neuropsychiatric disorders.

Andreas Meyer-Lindenberg1, Caroline F Zink

  • 1Unit for Systems Neuroscience in Psychiatry, Bethesda, MD 20892, USA. andresm@mail.nih.gov

Child and Adolescent Psychiatric Clinics of North America
|June 15, 2007
PubMed
Summary

Imaging genetics combines neuroimaging and genetic assessment to understand brain abnormalities in neuropsychiatric disorders. This approach reveals neural circuitry controlling emotional regulation and social cognition, influenced by genetic factors.

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Neuropsychiatric disorders in children and adolescents often have a significant genetic basis.
  • Understanding the neural underpinnings of complex behavioral and cognitive phenotypes is crucial.
  • Imaging genetics offers a powerful strategy to link genetic variations to brain function.

Purpose of the Study:

  • To review the application of imaging genetics in understanding neuropsychiatric disorders.
  • To present findings on the neural mechanisms of Williams syndrome.
  • To examine neural systems associated with genetic variation and psychiatric risk.

Main Methods:

  • Utilizing a multimodal neuroimaging approach combined with genetic assessment.
  • Dissecting neural mechanisms underlying the Williams syndrome phenotype.
  • Investigating gene-environment interactions in psychiatric disorder risk.

Main Results:

  • Identification of neural systems linked to genetic abnormalities and variation.
  • Dissection of neural mechanisms contributing to the Williams syndrome phenotype.
  • Evidence for genetic control over neural circuitry involved in emotional regulation and social cognition.

Conclusions:

  • Imaging genetics is a valuable strategy for dissecting the neural basis of complex neuropsychiatric disorders.
  • Genetic factors play a significant role in shaping neural circuitry for social cognition and emotional regulation.
  • Convergent evidence supports the genetic control of neural systems mediating social and emotional behaviors.