Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations between genetic ancestry and allergic outcomes at 10 years among Black children.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Investigating the Association Between Volatile Organic Compounds and Preterm Birth in Detroit, Michigan: Protocol for the Center for Leadership in Environmental Awareness and Research Birth Cohort Study.

JMIR research protocols·2026
Same author

Unsupervised characterization of 100,272 EHR patients identifies high-risk groups and comorbidities linked to premature aging.

NPJ digital medicine·2026
Same author

Author Correction: Transformer patient embedding using electronic health records enables patient stratification and progression analysis.

NPJ digital medicine·2026
Same author

Performance of Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the All of Us Program.

Circulation. Genomic and precision medicine·2026
Same author

Comparative Analysis of Report-back of Research Results Strategies for Personal Chemical Exposure Data.

Journal of exposure science & environmental epidemiology·2026

Related Experiment Video

Updated: May 12, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Coronary artery calcification progression is heritable.

Andrea E Cassidy-Bushrow1, Lawrence F Bielak, Patrick F Sheedy

  • 1Department of Epidemiology, University of Michigan, 611 Church St, Ann Arbor, MI 48104-3028, USA.

Circulation
|June 15, 2007
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly influence coronary artery calcification (CAC) progression. Many genes affecting initial CAC also impact its advancement, highlighting the genetic architecture of atherosclerosis.

More Related Videos

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Related Experiment Videos

Last Updated: May 12, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Area of Science:

  • Cardiovascular Genetics
  • Medical Imaging
  • Biostatistics

Background:

  • Coronary artery calcification (CAC) is a key indicator of coronary artery atherosclerosis.
  • Electron beam computed tomography enables accurate, noninvasive CAC measurement and serial progression quantification.
  • The role of genetics in CAC progression remains largely unexplored.

Purpose of the Study:

  • To quantify the contributions of genetic and environmental factors to CAC progression.
  • To investigate the genetic correlation between baseline CAC and its progression.

Main Methods:

  • Utilized electron beam computed tomography for serial CAC measurements in 877 adults from 625 families.
  • Employed statistical models to estimate heritability and genetic correlations, adjusting for risk factors and baseline CAC.

Main Results:

  • Heritability of CAC progression was estimated at 0.40, indicating significant genetic influence.
  • Genetic factors accounted for 14% of the variation in CAC progression.
  • A strong genetic correlation (0.80) was observed between baseline CAC quantity and its progression.

Conclusions:

  • Genetic factors play a substantial role in both the initial presence and the progression of CAC.
  • Shared genetic influences underscore the importance of understanding the genetic architecture of coronary artery atherosclerosis.
  • Further research into specific genetic factors can offer insights into disease mechanisms and potential therapeutic targets.