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A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
Cardiovascular disease and subsequent kidney disease
Essam F Elsayed1, Hocine Tighiouart, John Griffith
1Division of Nephrology, Department of Medicine, Tufts-New England Medical Center, Campus Box 391, Boston, MA 02111. dweiner@tufts-nemc.org.
Archives of Internal Medicine
|June 15, 2007
Summary
Cardiovascular disease (CVD) is a significant risk factor for kidney disease progression. This study found that existing CVD independently increases the likelihood of developing kidney disease and experiencing kidney function decline.
Area of Science:
- Nephrology
- Cardiology
- Epidemiology
Background:
- Chronic kidney disease (CKD) is a known risk factor for cardiovascular disease (CVD).
- The reciprocal relationship, where CVD may contribute to kidney disease, remains less understood.
- Investigating the impact of CVD on kidney health is crucial for comprehensive patient care.
Purpose of the Study:
- To determine if prevalent cardiovascular disease (CVD) is a risk factor for the progression or development of kidney disease.
- To analyze the association between baseline CVD and subsequent kidney function decline and kidney disease incidence.
- To provide evidence for the independent role of CVD in renal health outcomes.
Main Methods:
- Pooled individual patient data from two longitudinal, community-based studies (Atherosclerosis Risk in Communities Study and Cardiovascular Health Study).
- Baseline CVD defined by a history of stroke, angina, claudication, transient ischemic attack, coronary angioplasty/bypass, or myocardial infarction.
- Kidney function decline and kidney disease development assessed using changes in serum creatinine levels and estimated glomerular filtration rate (eGFR) over a mean follow-up of 9.3 years.
- Multivariate logistic regression analysis employed to evaluate the association between CVD and kidney outcomes.
Main Results:
- The study included 13,826 individuals, with 12.9% having baseline CVD.
- Over approximately 9 years, 3.8% experienced kidney function decline and 2.3% developed kidney disease.
- Baseline CVD was significantly associated with an increased risk of both kidney function decline (OR, 1.70) and kidney disease development (OR, 1.54).
Conclusions:
- Cardiovascular disease is an independent risk factor for kidney function decline.
- Prevalent cardiovascular disease is also independently associated with the development of kidney disease.
- These findings highlight the interconnectedness of cardiovascular and kidney health.
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