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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

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Published on: August 14, 2019

Urinary and erectile dysfunction in multiple system atrophy (MSA).

A G Papatsoris1, S Papapetropoulos, C Singer

  • 1Second Department of Urology, School of Medicine, University of Athens, Sismanoglio General Hospital, Athens, Greece.

Neurourology and Urodynamics
|June 15, 2007
PubMed
Summary

Multiple system atrophy (MSA) causes significant urogenital and erectile dysfunction (ED) in men. Early recognition and management of these symptoms, including recurrent lower urinary tract infections (UTIs), are crucial for improving patient outcomes.

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Area of Science:

  • Neurology
  • Urology

Background:

  • Multiple system atrophy (MSA) is a rare, sporadic neurodegenerative disorder.
  • It presents with parkinsonian, autonomic, cerebellar, and pyramidal symptoms.
  • Urogenital and erectile dysfunction (ED) are early and prominent features in male MSA patients.

Purpose of the Study:

  • To review the range of urological symptoms in MSA patients.
  • To discuss therapeutic approaches for storage and voiding lower urinary tract symptoms (LUTS) and ED in MSA.
  • To highlight the diagnostic challenges and potential for misdiagnosis with conditions like benign prostatic hyperplasia (BPH).

Main Methods:

  • This is a review article.
  • It synthesizes current knowledge on urogenital and ED symptoms in MSA.
  • It discusses management strategies based on existing literature.

Main Results:

  • Recurrent lower urinary tract infections (UTIs) affect over 50% of MSA patients, contributing to significant morbidity and mortality.
  • Urogenital symptoms stem from central and peripheral nervous system abnormalities, often complicated by pre-existing conditions like BPH.
  • Misdiagnosis of MSA-related urological symptoms as BPH can lead to inappropriate surgeries.

Conclusions:

  • Effective symptomatic therapies can temporarily alleviate some MSA symptoms.
  • Understanding the specific urological and ED phenotypes in MSA is vital for accurate diagnosis and management.
  • Addressing urogenital issues is critical for reducing mortality and improving quality of life in MSA patients.