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Updated: Jul 14, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
Published on: October 3, 2012
Genetics of Parkinson's disease and parkinsonism
Michael R Douglas1, Alistair J Lewthwaite, David J Nicholl
1University of Birmingham Medical School, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK. m.r.douglas@blueyonder.co.uk
Abstract:
The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased our understanding of the clinical and pathological changes underlying Parkinson's disease, with implications for patient diagnosis, management and future research. This review will outline the specific genetic advances, discuss their implications for clinical practice and hint at future directions for research into this common and disabling disease.
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