Matrix metalloproteinase-2 dysregulation in type 1 diabetes

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Kathryn M Thrailkill1, Robert C Bunn, Cynthia S Moreau

  • 1Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, Arkansas 72202, USA. thrailkillkathrynm@uams.edu

Diabetes Care
|June 15, 2007
PubMed
Abstract

Insights

Matrix metalloproteinase-2 (MMP-2) is dysregulated in type 1 diabetes, with elevated urine and plasma levels. Urinary MMP-2 may serve as a biomarker for diabetes-induced kidney damage.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Nephrology

Background:

  • Matrix metalloproteinase-2 (MMP-2) dysregulation is implicated in diabetes complications like retinopathy and cardiovascular disease.
  • Understanding MMP-2's role in type 1 diabetes is crucial for managing associated pathologies.

Purpose of the Study:

  • To investigate systemic MMP-2 dysregulation in type 1 diabetes.
  • To correlate MMP-2 concentrations with disease status and complications.

Main Methods:

  • Cross-sectional study of 93 type 1 diabetic and 50 healthy individuals (aged 14-40).
  • Measured plasma and urine MMP-2 concentrations and plasma MMP-2 activity.
  • Analyzed relationships with glycemic control, renal function, and disease duration.

Main Results:

  • Significantly elevated urine and plasma MMP-2 concentrations and plasma MMP-2 activity in type 1 diabetic subjects.
  • Urine MMP-2 correlated with higher A1C, longer disease duration, renal hyperfiltration, and microalbuminuria.
  • These correlations suggest increased risk for diabetic comorbidity and nephropathy.

Conclusions:

  • MMP-2 concentrations are dysregulated in both plasma and urine in type 1 diabetes.
  • Urinary MMP-2 excretion shows potential as a specific biomarker for diabetes-induced intrarenal pathological processes.

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