Related Experiment Video
Updated: Aug 16, 2026

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training
Published on: January 29, 2017
Placebo and analgesic nitrous oxide for treatment of the alcohol withdrawal state
1South African Brain Research Institute, Johannesburg.
Abstract:
We present evidence that analgesic (as distinct from anaesthetic) nitrous oxide is superior to placebo in the treatment of the alcohol withdrawal state. 'Carbogen' as a placebo is as effective as oxygen or medical air. However, placebo alone offers a means of treating the alcohol withdrawal state with a minimum of pharmacological intervention. Analgesic nitrous oxide for those not responding to placebo is a very rapid, effective, and extremely safe treatment which also reduces the use of highly addictive sedative pharmacological agents. This therapy also provides a rapid method of screening those patients requiring intensive monitoring and treatment in hospital from those who might benefit from out-patient therapy alone.
Related Concept Videos
Skeletal Muscle Relaxants: Therapeutic Uses
CNS Depressants: Alcohol and Nicotine
Parenteral Anesthetics: Overview
Inhalational Anesthetics: Overview
Drug Delivery: Enteral Route
Drugs in...
Depressants
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...

