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Related Experiment Videos

Planar cell polarity: one or two pathways?

Peter A Lawrence1, Gary Struhl, José Casal

  • 1Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. pal@mrc-lmb.cam.ac.uk

Nature Reviews. Genetics
|June 15, 2007
PubMed
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Planar cell polarity (PCP) involves at least two independent genetic pathways, not one as previously thought. This finding redefines our understanding of how cells orient themselves in tissues.

Area of Science:

  • Developmental Biology
  • Genetics
  • Cell Biology

Background:

  • Multicellular organisms exhibit planar cell polarity (PCP), where cells align within epithelial sheets, often indicated by structures like cilia.
  • Genes controlling PCP in Drosophila melanogaster are conserved in vertebrates, highlighting evolutionary importance.
  • Understanding PCP is crucial for developmental processes and tissue organization.

Purpose of the Study:

  • To dissect the underlying genetic logic of planar cell polarity (PCP).
  • To challenge the prevailing notion of a single genetic pathway governing PCP.
  • To propose a revised model for PCP based on experimental evidence.

Main Methods:

  • Review of genetic mosaic studies in adult Drosophila melanogaster.

Related Experiment Videos

  • Analysis of how polarizing information is generated and transmitted between cells.
  • Comparative analysis of gene function in cell-cell communication and polarity establishment.

    • Main Results:

    • Evidence suggests that planar cell polarity (PCP) is regulated by at least two distinct genetic pathways.
    • These pathways appear to operate independently in establishing cell polarity.
    • Genetic mosaics reveal complex interactions in the generation and propagation of polarity signals.

    Conclusions:

    • The established view of a single genetic pathway for PCP is incorrect.
    • At least two independent processes contribute to planar cell polarity.
    • This revised understanding has significant implications for future research in the PCP field.