Related Experiment Video
Updated: Jul 14, 2026
06:45
Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
Published on: December 18, 2010
Soluble Fas and soluble FasL in multiple organ dysfunction syndrome complicating diffuse peritonitis
Michihiko Kitamura1, Shigetasu Endo, Nobuhiro Sato
1Department of Surgery, Iwate Prefectural Isawa Hospital, 61 Tatsugababa, Mizusawa 023-0864, Japan.
Research Communications in Molecular Pathology and Pharmacology
|June 15, 2007
Summary
Serum levels of sFas and TNF-alpha were higher in non-survivors of multiple organ dysfunction syndrome (MODS), while sFasL was higher in survivors. FasL-Fas system changes may impact MODS pathogenesis.
Area of Science:
- Immunology
- Cellular Biology
- Pathophysiology
Background:
- The Fas ligand (FasL)-Fas receptor system is a key mediator of apoptosis.
- Multiple Organ Dysfunction Syndrome (MODS) is a critical condition with high mortality.
- Understanding the role of apoptosis pathways in MODS is crucial for developing therapeutic strategies.
Purpose of the Study:
- To investigate the association between serum levels of soluble Fas ligand (sFasL), soluble Fas (sFas), and tumor necrosis factor-alpha (TNF-alpha) and the severity of MODS.
- To determine if these markers can predict patient outcomes in MODS.
Main Methods:
- Serum samples were collected from 20 patients with MODS complicating generalized peritonitis.
- Concentrations of sFas, sFasL, and TNF-alpha were measured.
- Levels were compared between patients who survived and those who died.
Main Results:
- Serum sFas and TNF-alpha levels were significantly elevated in non-survivors compared to survivors.
- Serum sFasL levels were significantly higher in survivors than in non-survivors.
- A significant positive correlation was found between serum TNF-alpha and sFas levels.
Conclusions:
- Alterations in the FasL-Fas system, including elevated sFas and TNF-alpha, are associated with increased mortality in MODS.
- Higher sFasL levels in survivors suggest a potential protective or compensatory role.
- These findings indicate that the FasL-Fas pathway may play a significant role in MODS pathogenesis.
Related Concept Videos
01:21Acute Pancreatitis II: Pathophysiology
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
01:25Acute Inflammation III: Local and Systemic Effects
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...