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Acute monoblastic leukemia (FAB-M5b) with t(8;14)(p11;q11.1)
M L Slovak1, L Nemana, S T Traweek
1Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA.
Cancer Genetics and Cytogenetics
|October 15, 1991
Abstract:
A case of acute monocytic leukemia (FAB-M5b) expressing natural killer cell-associated antigens containing a t(8;14)(p11;q11.1) is presented. We interpret this translocation to represent a variant of the t(8;16) previously reported in FAB-M5b. These findings support the contention that the 8p11 breakpoint site is the critical junction in the oncogenesis of acute monoblastic leukemia with differentiation.