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FISH for Pre-implantation Genetic Diagnosis
Published on: February 24, 2011
Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes
J R Sawyer1, C M Swanson, G J Roloson
1Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.
Cancer Genetics and Cytogenetics
|December 1, 1991
Abstract:
Cytogenetic analysis of a medulloblastoma revealed two abnormal cell lines of 48,XY, +8, +8, -14, +der(14)t(1;14)(q11;p11),i(17q) and 51,XY, +5, +6, +8, +8, -14 + 20, +der (14)t(1;14)(q11;p11),i(17q), + dmin. The finding of double minute chromosomes in some medulloblastomas has been associated with amplification of the c-myc or N-myc oncogenes. We were unable to detect gene amplification with these probes by Southern blot analysis.

