Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Direct-Acting Cholinergic Agonists: Therapeutic Uses01:11

Direct-Acting Cholinergic Agonists: Therapeutic Uses

Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren syndrome.
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concerns About Chocolate Consumption and Indicators of Adiposity.

The American journal of medicine·2021
Same author

Physicians and Duty During a Pandemic: A Response.

The American journal of medicine·2020
Same author

Idiopathic pulmonary vein thrombosis?

Respirology case reports·2018
Same author

Cobblestone Airways.

Mayo Clinic proceedings·2016
Same author

A Man With Intractable Convulsion.

Infectious diseases in clinical practice (Baltimore, Md.)·2016
Same author

Congenital pulmonary airway malformation in a 36 year-old female.

Respiratory medicine case reports·2016

Related Experiment Video

Updated: Jul 14, 2026

In vivo Evaluation of Mucociliary Clearance in Mice
06:35

In vivo Evaluation of Mucociliary Clearance in Mice

Published on: December 18, 2020

Methacholine challenge testing: identifying its diagnostic role, testing, coding, and reimbursement.

Sam Birnbaum1, Timothy J Barreiro

  • 1Division of Pulmonary and Critical Care Medicine, Northeastern Ohio Univeristies College of Medicine, Ohio University College of Osteopathic Medicine, OH, USA. sam@mypracticeconsultant.com

Chest
|June 15, 2007
PubMed
Summary

Methacholine challenge testing (MCT), a type of bronchoprovocation, aids in diagnosing asthma when standard tests are normal. This guide details MCT procedures, coding, and reimbursement for clinical and research use.

More Related Videos

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
06:39

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders

Published on: August 18, 2016

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
05:32

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia

Published on: January 19, 2022

Related Experiment Videos

Last Updated: Jul 14, 2026

In vivo Evaluation of Mucociliary Clearance in Mice
06:35

In vivo Evaluation of Mucociliary Clearance in Mice

Published on: December 18, 2020

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
06:39

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders

Published on: August 18, 2016

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
05:32

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia

Published on: January 19, 2022

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Methacholine challenge testing (MCT), or bronchoprovocation, is crucial for diagnosing asthma.
  • It is particularly useful for patients with asthma-like symptoms but normal spirometry.
  • MCT is commonly conducted in pulmonary function labs, clinics, or offices.

Purpose of the Study:

  • To outline standard methacholine challenge testing protocols.
  • To provide guidance on coding and reimbursement for MCT.
  • To enhance understanding and application of MCT in clinical and research settings.

Main Methods:

  • Review of established methacholine challenge testing procedures.
  • Identification of standard testing regimens.
  • Analysis of coding and reimbursement methodologies.

Main Results:

  • Two standard methacholine challenge testing protocols were identified.
  • Appropriate coding and reimbursement strategies were outlined.
  • The study emphasizes the practical aspects of performing MCT.

Conclusions:

  • Methacholine challenge testing is a valuable diagnostic tool for asthma.
  • Standardized protocols and clear reimbursement guidelines facilitate MCT's use.
  • Understanding MCT procedures is essential for accurate diagnosis and research.