Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gabapentin-induced severe myopathy.

Marco Tuccori1, Giuseppe Lombardo, Francesco Lapi

  • 1Tuscan Regional Center for Pharmacovigilance, University of Pisa, Pisa, Italy.

The Annals of Pharmacotherapy
|June 15, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum benzylpenicillin levels during treatment for amatoxin poisoning: pharmacokinetic support for OATP1B3 inhibition.

Clinical toxicology (Philadelphia, Pa.)·2026
Same author

Biosimilars in allergology: an outline in pediatric patients.

Current opinion in allergy and clinical immunology·2026
Same author

Adherence to Stillbirth Guidelines and Women's Psychological Well-Being: The CLASS (CiaoLApo Stillbirth Support) Cross-Sectional Study.

Birth (Berkeley, Calif.)·2026
Same author

AI and the human mind: only one is a black box.

Nature·2026
Same author

Disseminated Intravascular Coagulation Following Idarucizumab and Andexanet Alfa: Assessment of a Signal of Disproportionate Reporting From the Food and Drugs Administration Adverse Event Reporting System (FAERS) Database.

Drug safety·2026
Same author

The LISTEN (Lactation Support afTer pEriNatal loss) Project: Pathways of Loss and Lactation Care in Italy.

Journal of midwifery & women's health·2025

This case report highlights a rare instance of severe myopathy and acute kidney injury in an elderly patient treated with gabapentin for neuropathic pain. The adverse event resolved after discontinuing gabapentin, suggesting a probable causative role.

Area of Science:

  • Neurology
  • Pharmacology
  • Nephrology

Background:

  • Neuropathic pain is common in elderly diabetic patients.
  • Gabapentin is frequently prescribed for neuropathic pain.
  • Adverse drug reactions can be severe in the elderly population.

Observation:

  • An 85-year-old woman with diabetic neuropathic pain developed severe myopathy and acute renal failure shortly after initiating gabapentin therapy.
  • Initial laboratory tests were normal, but creatine kinase and myoglobin levels significantly elevated during treatment.
  • Symptoms improved rapidly after gabapentin withdrawal, despite continued use of other medications.

Findings:

  • Gabapentin was identified as the probable cause of myopathy and acute kidney injury based on the Naranjo probability scale.

Related Experiment Videos

  • The patient experienced psychomotor agitation and gastric pain, potentially related to co-administered haloperidol and lansoprazole.
  • Muscle and nerve histopathologic examinations are recommended for further investigation.

    • Implications:

    • Clinicians should be aware of the potential for severe myopathy as an idiosyncratic adverse reaction to gabapentin.
    • Consider gabapentin-induced myopathy in patients presenting with unexplained muscle pain and elevated creatine kinase levels.
    • Further research is needed to elucidate the mechanisms of gabapentin-related myopathy.